Iminosugar-based glycopolypeptides: glycosidase inhibition with bioinspired glycoprotein analogue micellar self-assemblies.

نویسندگان

  • Colin Bonduelle
  • Jin Huang
  • Teresa Mena-Barragán
  • Carmen Ortiz Mellet
  • Camille Decroocq
  • Emile Etamé
  • Andreas Heise
  • Philippe Compain
  • Sebastien Lecommandoux
چکیده

Biomimetic nanoparticles prepared by self-assembly of iminosugar-based glycopolypeptides evidenced remarkable multivalency properties when inhibiting α-mannosidase activity. This approach paves the way to obtain biologically active drug delivery systems having glycosidase inhibition potency.

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عنوان ژورنال:
  • Chemical communications

دوره 50 25  شماره 

صفحات  -

تاریخ انتشار 2014